https://www.kwapislab.com/home daily 1.0 2025-03-18 https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1529639707820-GE5ZCG0HN809KWHVV1RV/KwapisLab+Logo+LONG.jpg Home https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1529939286483-NQ5FO5L3T5IKFH8VDM7P/Black+background.jpg Home https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1519013395843-0AD462E2T66NY9CQN1IR/PM+example+website.jpg Home - Kwapis Lab Penn State University https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/fb058b28-c627-4844-9247-4360ea9a2276/Artboard+1%402x.png Home https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/f5d990cd-290f-42d1-ab38-05e72e1df299/WIL+Safer+spaces+logos.jpg Home - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.kwapislab.com/research daily 0.75 2025-07-28 https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1519161230315-C111W0M4QUAPHIMV6WGE/WholeHemiBbrighter.jpg Research Our research uses cutting-edge techniques to dissect the molecular mechanisms that underlie memory and age-related memory decline. These techniques include: -in vivo CRISPRi and CRISPRa to reduce or drive transcription in a site- and circuit-specific manner -Cloning, cell culture, and viral vectors to manipulate gene expression or activity -CatFISH and viral TetTag to capture and visualize active neuronal ensembles and chemogenetics to manipulate those ensembles - Molecular and cellular biology techniques including RT-qPCR, western blots, immunofluorescence, chromatin immunoprecipitation, RNA-seq, etc. -Sophisticated behavioral techniques, including fear conditioning, stress-enhanced fear learning (SEFL), object location/recognition memory, memory updating paradigms, etc. https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/b6b54068-1b0d-4022-aae8-09a5797790e3/Copy+of+Alt.+RSC_SCN+Model.png Research Age-related epigenetic repression of Per1 could have different outcomes depending on the brain region affected. 1: Urban et al., 2021; Brunswick et al., 2023; 2: Kwapis et al., 2019; Bellfy et al., 2023 https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/b969688e-ba73-4d1c-b2eb-2c9d28acb592/TetTag+Example.png Research - Make it stand out Viral TetTag combined with cFos labelling to identify neurons engaged by initial memory formation and subsequent updating. https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/fc3f62c4-f0f9-48ef-b26a-6f68896bad8e/SEFL+Hypothesis+for+Website.png Research - Make it stand out Proposed mechanism underlying the SEFL paradigm. A) In the absence of the trauma event, HDAC3 maintains a restrictive chromatin state in the basolateral amygdala, minimizing mRNA expression during subsequent fear conditioning and forming a very weak fear memory. B) Following the trauma event, HDAC3 is kicked off of the chromatin in the basolateral amygdala, permitting extensive acetylation and an open chromatin state that allows for substantial mRNA expression during subsequent fear conditioning and the formation of a strong fear memory. https://www.kwapislab.com/janine daily 0.75 2025-12-10 https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1571940987337-84QXEOCI865VVBJES05M/jlk855.jpg About Janine jlk855@psu.edu https://www.kwapislab.com/contact daily 0.75 2026-03-31 https://www.kwapislab.com/publications daily 0.75 2026-03-19 https://www.kwapislab.com/people daily 0.75 2026-03-18 https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/43eedc4d-1d32-422f-a9fe-185ee4478e3c/Janine.png Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/b9e4082d-d9ee-4075-9248-d5cbb7cc3d54/Shoko%2Bheadshot.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/8363b9c3-eff4-4664-8c07-364a8ec10593/Joan+Big.png Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/96ac1c0b-3663-42e9-a8ea-a6cc32d1af3d/ChadS.png Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/354ba9cc-2c9f-4955-b911-2a745a74df97/Gretchen.png Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/41e0b528-5cfe-4f42-a478-258e56a5d8a4/Megan.png Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/0f6528ce-f48f-4c7b-ba02-48fd80b39c62/Trinity.png Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/45153f56-30a2-4789-9b4c-8b02aa7f22b9/Evan.png Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/96e6aae3-ac9b-4c34-a243-edc860a4d63b/ChadB.png Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/8b321eb6-0c83-44e4-91eb-d5faea41fc7f/Shannon.png Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/4d982af4-cde5-4540-a5a4-938adefc88fe/Cyrus.png Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/e79c98a4-a052-4a87-980d-069d237e0baa/Marc.png Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/75201d8a-af33-499a-9e42-b132db433559/chloe_williams.png Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1601671415347-XGLDKOYJSA28MBFSW2PW/KwapisLab+Logo+for+ALUMNI-01-01-01.png Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/8aaad65e-080c-4f23-9edd-e02efe16328c/Hannah.png Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/0fea96f4-5186-4178-b529-3bdb78e75c5a/Annie.png Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/cc22aa95-b665-4ac3-8c65-c44f63bb6609/Madison.png Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/62abc2f4-3d5e-4998-b54b-3c9bcbd40576/Landyn.png Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/501813b9-2f50-4d7f-9bf3-7f1f800c39f4/Cara+Schmidt.png Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1571940408029-1UVNGM9CR7SYFK9GOSUY/IMG_1062.jpeg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1756994639225-BS9EQY9YEQMKTYRNLC7Q/IMG_8232.jpeg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1740772455719-EYT8ELUONZP6RUCWU4OO/Lab+group+photo+2025.png Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1730399623071-DN691OFDCRJPDTX4RCBF/IMG_2387.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1756994636361-S13Y5GCQG12ZZPXG3XKK/IMG_9428.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1756994637424-49YIE2SLJ2BZV8TI1LAT/IMG_9699.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1761049727282-43F547J7OUBFVTK8E0SH/IMG_8375.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1771422182235-H62NUEAJBVTZBDTHN098/e5077dcd-50e0-4955-98c1-fe49f97f4650.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1756994636321-BKKRRAW5YSO9V69HKWU8/PXL_20250626_081636099.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1725553315385-46NRX5TVZ9CI27J1PY9S/IMG_1861.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1701966951900-3PBAIL61DZD88ZMKH2KC/IMG_0973.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1696509475756-WKOCWG2J7NO246QG3IOT/IMG_0119.jpeg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1701966952199-F7LT6IVPMA2LV3WFM5CW/IMG_1033.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1699985337634-HLQN9I01VZK332VLOKAK/img_0645.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1699985422604-7SKR5S3JY258LSZ39KK3/IMG_0635.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1699985336505-SJM5LR8BP530IT03K95N/img_0637.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1756994740227-4A0T3IJ5A0NZWE8I5XK0/IMG_9389.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1650303322116-MAHSBI4AL7ALYA4N40IL/thumbnail_IMG_2376.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1664815824674-1GGWOA1WH0N3SIUSYM83/B63D6E2D-8A12-49E6-8316-6FA8BBB89DCB_1_102_a.jpeg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1670080262341-VP4J53JB9R5DG48KN4YE/img_7275.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1664815824588-46LW5IW0VEWJN1RMIWDT/D49E60D2-D69D-41F6-865D-307C96CFB545_1_102_a.jpeg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1661198753111-XL1M21YVIGZTGLC0EJC3/IMG_6259.JPEG Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1648497443752-UFS976JW8E5FIRPX1MN6/thumbnail_IMG_3972.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1699985336690-6PGH4XW9L9X5EI9WHZPC/img_0639.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1670080419894-O9KLZ1QI7FNJLQD58IB9/IMG_7070.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1670080264005-PYXELCH81QWQ5TM1LO34/IMG_7123.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1652899691279-X0OK3GLX9FZX74RWM9KM/shoko.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1661603356402-E8M4CQSEYN60JGNU6LJ3/img_4336.jpg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1571940405277-0GXT2MBK600TRQPAFMOW/IMG_0732.jpeg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1571940418447-AK6Y9R7GE63HB126ZJR6/IMG_1591.jpeg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1571940407001-P79XTCYSUAJ43DR2MK3X/IMG_0908.jpeg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1571940412911-1KZUK2XV74RANI8761S9/IMG_1507.jpeg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1571940405369-U7Q9NYNJLH05URO74YQM/IMG_0684.jpeg Lab Members https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/ce772482-d145-404a-b4ab-5683b4f16fb3/IMG_1301+small.jpg Lab Members - Make it stand out Whatever it is, the way you tell your story online can make all the difference. https://www.kwapislab.com/alumni daily 0.75 2026-02-19 https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/7ca5efb6-b5fc-414d-af5c-b7ea088064e4/Achintya2.png KwapisLab Alumni - Achintya Perumal Kwapis Lab Undergraduate Researcher https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/bd081883-e6b6-453d-91f7-b07c9fa1d6d5/Lauren3.webp KwapisLab Alumni - Lauren Bellfy Kwapis Lab PhD student Current position: Postdoctoral scholar, Pan Group, Broad Institute https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/27d13482-215b-45c4-99c1-cb21b7c4f8b6/Derek2.png KwapisLab Alumni - Derek Baldwin Kwapis Lab Undergraduate Researcher https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/0a18fa73-995b-42d2-9c1e-deebc7b4f330/keppler2.png KwapisLab Alumni - Liam Keppler Kwapis Lab Undergraduate Researcher https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/61b28e0d-74ad-4a91-b124-d7aa6c9d75a1/Sofia.png KwapisLab Alumni - Sofia Bennetts Kwapis Lab Undergraduate Researcher Current position: PhD student, McKinley Lab, Harvard University https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/ccbe887d-6009-4b9c-9ddb-3421fb48fc66/Alex.png KwapisLab Alumni - Alexandria McKenna Kwapis Lab Undergraduate Researcher Current position: PhD student, Microvascular Research Laboratory, Penn State University https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/6688b283-bcef-4f4d-ac11-e3cf74d95712/Marc.png KwapisLab Alumni - Marc Lussier Kwapis Lab Undergraduate Researcher Current position: Medical student, Penn State College of Medicine https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/c285ee52-499f-4f7d-807d-25c0fbf4fb8f/Alicia.png KwapisLab Alumni - Alicia Bernhardt Kwapis Lab Undergraduate Researcher Current position: Medical student, Penn State College of Medicine https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/7dbc10a9-01a0-43f8-a3af-df0af9a44164/Jordan.png KwapisLab Alumni - Jordan Futrell Kwapis Lab Undergraduate Researcher https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/9570a9bd-b211-4bd9-81ff-5689bba21cdd/Dawn.png KwapisLab Alumni - Dawn Johnson Kwapis Lab Undergraduate Researcher https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/402bbb6d-204e-48f6-8c86-6cabeab75238/Mark.png KwapisLab Alumni - Mark Urban, PhD Kwapis Lab Postdoctoral Scholar Current position: Senior Research Investigator in the University of Pennsylvania Gene Therapy Program https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1601668456721-W8LI69GKKVC89K4PMBDB/image-asset.jpeg KwapisLab Alumni - Kasuni Bodinayake Kwapis Lab Research Technician Current position: Graduate student, Dr. Sean Ostlund lab, University of California, Irvine https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1601668812997-53RAP2HQUHAHZNEWM86Z/Ashley%2Bheadshot.jpg KwapisLab Alumni - Ashley Heimann Kwapis Lab Undergraduate Researcher Current position: Postbac at NIH https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1601669143241-WMG54PDT9TVX8133EH97/Will%2Bheadshot.jpg KwapisLab Alumni - Yunsik (Will) Won Kwapis Lab Undergraduate Researcher Current position: Research Staff, Soram Hospital of Korean Medicine https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1601669195649-NDLYKGMDSWJD7ZT60WE4/Shagun+New+headshot.jpeg KwapisLab Alumni - Shagun Lakhia Kwapis Lab Undergraduate Researcher https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1622567739270-6HUOGNY8WFHLSTMFNJBL/Emily+Headshot.jpeg KwapisLab Alumni - Emily Stuart Kwapis Lab Undergraduate Researcher Current position: Medical student, Temple University https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/1611017545035-RJTMFNSX1PJKCL1ZMCL4/De%27Jah+headshot2.jpg KwapisLab Alumni - De’jah Coates Kwapis Lab Undergraduate Researcher https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/99399d55-92e9-48b9-aad6-2ab36d73ca1a/Destiny%2Bheadshot.jpg KwapisLab Alumni - Destiny WRight Kwapis Lab Undergraduate Researcher Current position: Graduate student, University of Pittsburgh https://images.squarespace-cdn.com/content/v1/5a8a2b97692ebefdc3fad5af/9d171b07-ba63-498b-9121-25274d4c0445/Milo%2Bheadshot.jpg KwapisLab Alumni - CHen-yu Lo Kwapis Lab Undergraduate Researcher Current position: Medical student at Tsing-Hua University